CENTRIOLE REPLICATION
نویسندگان
چکیده
منابع مشابه
Centriole Replication
This paper describes the replication of centrioles during spermatogenesis in the Prosobranch snail, Viviparus malleatus Reeve. Sections for electron microscopy were cut from pieces of testis fixed in OsO(4) and embedded in the polyester resin Vestopal W. Two kinds of spermatocytes are present. These give rise to typical uniflagellate sperm carrying the haploid number of 9 chromosomes, and atypi...
متن کاملOverexpressing Centriole-Replication Proteins In Vivo Induces Centriole Overduplication and De Novo Formation
BACKGROUND Centrosomes have important roles in many aspects of cell organization, and aberrations in their number and function are associated with various diseases, including cancer. Centrosomes consist of a pair of centrioles surrounded by a pericentriolar matrix (PCM), and their replication is tightly regulated. Here, we investigate the effects of overexpressing the three proteins known to be...
متن کاملCentriole structure.
Centrioles are among the largest protein-based structures found in most cell types, measuring approximately 250 nm in diameter and approximately 500 nm long in vertebrate cells. Here, we briefly review ultrastructural observations about centrioles and associated structures. At the core of most centrioles is a microtubule scaffold formed from a radial array of nine triplet microtubules. Beyond t...
متن کاملRevisiting the role of the mother centriole in centriole biogenesis.
Centrioles duplicate once in each cell division cycle through so-called templated or canonical duplication. SAK, also called PLK4 (SAK/PLK4), a kinase implicated in tumor development, is an upstream regulator of canonical biogenesis necessary for centriole formation. We found that overexpression of SAK/PLK4 could induce amplification of centrioles in Drosophila embryos and their de novo formati...
متن کاملSnapShot: Centriole Biogenesis
an d d up lic at io n SPD2 (Ce, Dm)/ CEP192 (Hs) No centriole duplication (Ce); <PCM recruited (Ce, Dm, and Hs); no basal body duplication (Dm) Asterless (Dm)/ CEP152 (Dr, Hs) Aberrant PCM recruitment (Dm) and centriole duplication (Dm and Dr) γ-Tubulin (Dm, Hs, Tt, Pt)/TBG (Ce) Aberrant centriole duplication (Ce, Hs, Tt), centriole structure and separation (Pt, Dm) Overexpression: de novo form...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Biophysical and Biochemical Cytology
سال: 1961
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.10.2.163